From 10pm until 6am, the eastbound entry slip road at junction 12 (Theale) onto the M4 will be closed for four nights for surface repairs.
A diversion route will be in place via junction 13 (Chieveley).
There will also be a lane closure in place on the roundabout under junction 13, again between 10pm to 6am for four nights from tonight.
From tomorrow, the westbound entry slip road at junction 14 (Hungerford) will be closed for surface maintenance for two nights, and a diversion will be in place at the Chieveley junction.
On Wednesday, there will be lane closures between junctions 11 (Reading) and 12 (Theale) from 10pm to 5.30am.
Traffic will be directed to travel in the hard shoulder and a 50mph speed limit will be in place.