Motorists can expect delays on the A339 this week with one lane on the northbound carriageway due to be closed as part of the continuing widening project that started earlier this year.
The closure along the busy stretch south of the Robin Hood roundabout will be in place while the handrails on the bridge over the River Kennet are being refurbished.
To minimise disruption the closure will be limited to off-peak hours between 9.30am and 3.30pm daily.
West Berkshire Council say the handrail refurbishment, which started on Sunday, should be complete by Friday.
West Berkshire Council spokesman Martin Dunscombe added: "We know it gets busy before the weekend and we will be doing all we can to minimise disruption to the weekend getaway."
The works, which began in February, have seen lanes narrowed between the Robin Hood roundabout and the Bear Lane roundabout and a temporary 30mph speed limit introduced.
The project will eventually see the dual carriageway south of the Robin Hood roundabout widened before a new junction is installed leading on to the London Road Industrial Estate (LRIE).
The roadworks are expected to last until the end of the year paving the way for the redevelopment of the LRIE.