Newbury face derby trip down the A4
Almst the length of the table separates the teams, but Newbury manager Steve Melledew acknowledges that the derby element will close the gap.
"It's not Everton v Liveprool," he said, "but it still means something to a lot of players and these derby games always have a little bit extra and add an extra half a yard."
Newbury are without Danny Lachacz and Kalief Madden.
Newbury will also be in action on Monday night when they entertain Kidlington at Faraday Road in the Hellenic League's Supplementary Cup, bidding for a place in the quarter-finals of a competition that is having to be crammed into the latter weeks of the season.
"It's our last chance of winning a cup this season," said Melledew, "so we will be fielding the strongest side available."