Newbury in showdown with leaders
Highmoor are seven points clear of Newbury, who have four games in hand but go into the game on the back of a 2-2 draw at lowly Milton United last week.
"There's 30 points still to play for and if we lose, it's not all over and if we draw it would be a creditable result," said Newbury manager Steve Melledew.
"But I suppose that if we win, I shall have to change my opinion and start thinking that we can go up."
Newbury beat the leaders 4-1 at Faraday Road last August but Melldeew still rates Saturday's opponents highly.
He will be without defender Jamie Green and striker Marc Green on Saturday, but goalkeeper Andy Bayliss should return to an otherwise unchanged squad.